PUBLICATIONS
  1. Valderrama, J.A., Kulkarni, S.S., Nizet, V. et al. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019 Dec 16; 10: 5726.  
  2. Guichard A, Haque T, Bobik M, Xu XS, Klanseck C, Kushwah RBS, Berni M, Kaduskar B, Ganz VM, Bier E. Efficient allelic-drive in Drosophila. Nat Commun. 2019 Apr 9; 10(1): 1640. 
  3. Grunwald HA, Gnatz VM, Poplawski G, Xu XS, Bier E, Cooper KL. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2019 Feb; 566(7742): 105-109
  4. Negreiros E, Herszterg S, Kang KH,  Câmara A, Dias WB, Carneiro K, Bier E, Todeschini AR, Araujo H. N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs. Development. 2018 Nov 19; 145(22). pii: dev167338
  5. Liu JZ, Ali SR, Bier E, Nizet V. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018 Jan 22; 8:2
  6. Bier E, Harrison MM, O'Connoer-Giles KM, Wildonger J. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 Jan 01; 208(1): 1-18. 
  7. Bier, E.  (2017).  Two lines of research converge to create immunizing gene-drive mosquitoes.  Authorea: https://www.authorea.com/users/176044/articles/233842-two-lines-of-research-converge-to-create-immunizing-gene-drive-mosquitoes
  8. Xu XS, Gants VM, Siomava N, Bier E. CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila knirps-L2 CRM reveals unexpected complexity. eLife. 2017 Dec 23;6. pii: e30281.
  9. Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zuniga EI, Krug RM, Oldstone MB, Bier E. Influenza NS1 directly modulates Hedgehog signaling during infection. PLoS Pathog. 2017 Aug 24;13(8)e:1006588.
  10. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereux M, Ellsworth P, Friedman RM, Gantz VM, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. Rules of the road for insect gene drive research and testing. Nat Biotechnology. 2017 Aug 08;35(8):716-718
  11. Gantz VM, Bier E. The Dawn of Active Genetics. Bioessays. 2016 Jan;38(1):50-63.
  12. Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. PNAS. 2015 Dec 8;112(49):E6736-43. 
  13. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28;349(6251):927-9.
  14. Bier E, De Robertis EM. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning. Science. 2015 Jun 26;348(6242):aaa5838.
  15. Gantz VM, Bier E. Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015 Apr 24;348(6233):442-4.
  16. Bier E, Nizet V. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11;17(2):146-8.
  17. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep 11;10(9):e1004625.
  18. Guichard A, Nizet V, Bier E. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep;12(9):624-34.
  19. Guichard A, Cruz-Moreno B, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E.Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11;14(3):294-305.
  20. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5;16(3):311-21.
  21. Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov;7(11):e1002344.
  22. Bier E, Guichard A. Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech. 2012 Jan;5(1):48-61.
  23. Guichard A, Nizet V, Bier E. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.  Microbes Infect. 2012 Feb;14(2):97-118.
  24. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 1;360(1):230-40.
  25. Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul;2(7):554-63.
  26. Bier E. Evolution of development: diversified dorsoventral patterning. Curr Biol. 2011 Aug 9;21(15):R591-4.
  27. Do LH, Bier E. The Booly aliasing resource: a database of grouped biological identifiers. Bioinformation. 2011 Mar 26;6(2):83-5.
  28. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14;467(7317):854-8.
  29. Do LH, Esteves FF, Karten HJ, Bier E. Booly: a new data integration platform. BMC Bioinformatics. 2010 Oct 13;11:513.
  30. Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun;2(6):369-74. Review.
  31. Kang KH, Bier E. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Dev Biol. 2010 Oct 1;346(1):1-10.
  32. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 5;327(5970):1223-8.
  33. Reiter LT, Do LH, Fischer MS, Hong NA, Bier E. Accentuate the negative: proteome comparisons using the negative proteome database. Fly (Austin). 2007 May-Jun;1(3):164-71.
  34. Bier E. Intriguing extracellular regulation of BMP signaling. Dev Cell. 2008 Aug;15(2):176-7.
  35. Mizutani CM, Bier E. EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet. 2008 Sep;9(9):663-77.
  36. Iyadurai SJ, Robinson JT, Ma L, He Y, Mische S, Li MG, Brown W, Guichard A, Bier E, Hays TS. Dynein and Star interact in EGFR signaling and ligand trafficking. J Cell Sci. 2008 Aug 15;121(Pt 16):2643-51.
  37. Mizutani CM, Meyer N, Roelink H, Bier E. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. PLoS Biol. 2006 Oct;4(10):e313.
  38. Bier E. Antioxidants put Parkinson flies back in the PINK. PNAS. 2006 Sep 5;103(36):13269-70.
  39. Reiter LT, Seagroves TN, Bowers M, Bier E. Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet. 2006 Sep 15;15(18):2825-35.
  40. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. PNAS. 2006 Feb 28;103(9):3244-9.
  41. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug;233(4):1315-31.
  42. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun;8(6):915-24.
  43. Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet. 2005 Jan;6(1):9-23. Review.
  44. Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene. 2004 Nov 10;342(1):1-11. Review.
  45. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 6;305(5685):846.
  46. Yu K, Kang KH, Heine P, Pyati U, Srinivasan S, Biehs B, Kimelman D, Bier E. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004 Mar;166(3):1323-36.
  47. Cook O, Biehs B, Bier E. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development. 2004 May;131(9):2113-24. Epub 2004 Apr 8.
  48. Araujo H, Negreiros E, Bier E. Integrins modulate Sog activity in the Drosophila wing. Development. 2003 Aug;130(16):3851-64.
  49. Heriche JK, Ang D, Bier E, O'Farrell PH.  Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 4;4(1):9.
  50. Lunde K, Trimble JL, Guichard A, Guss KA, Nauber U, Bier E. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003 Jan;130(2):235-48.
  51. Reiter LT, Bier E. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 2002 Jun;6(3):387-99.
  52. Guichard A, Srinivasan S, Zimm G, Bier E. A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. PNAS. 2002 Mar 19;99(6):3752-7.
  53. Srinivasan S, Rashka KE, Bier E. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2002 Jan;2(1):91-101.
  54. Chien S, Reiter LT, Bier E, Gribskov M.  Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 2002 Jan 1;30(1):149-51.
  55. Reiter LT, Potocki L, Chien S, Gribskov M, Bier E.  A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001 Jun;11(6):1114-25.
  56. Guichard A, Roark M, Ronshaugen M, Bier E. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol. 2000 Oct 15;226(2):255-66.
  57. Araujo H, Bier E. sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development. 2000 Aug;127(16):3631-44.
  58. Bier E. Drawing lines in the Drosophila wing: initiation of wing vein development. Curr Opin Genet Dev. 2000 Aug;10(4):393-8. Review.
  59. Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka KE, Kimelman D, O'Connor MB, Bier E. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000 May;127(10):2143-54.
  60. Mohler J, Seecoomar M, Agarwal S, Bier E, Hsai J.  Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing. Development. 2000 Jan;127(1):55-63.
  61. Guichard A, Biehs B, Sturtevant MA, Wickline L, Chacko J, Howard K, Bier E.  rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development. 1999 Jun;126(12):2663-76.
  62. Bier E. Developmental biology. A unity of opposites. Nature. 1999 Apr 1;398(6726):375-6.
  63. Biehs B, Sturtevant MA, Bier E.  Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development. 1998 Nov;125(21):4245-57.
  64. Lunde K, Biehs B, Nauber U, Bier E.  The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development. 1998 Nov;125(21):4145-54.
  65. Bier E.  Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays. 1998 Mar;20(3):189-94. Review.
  66. Bier E. Anti-neural-inhibition: a conserved mechanism for neural induction. Cell. 1997 May 30;89(5):681-4. Review. No abstract available.
  67. Sturtevant MA, Biehs B, Marin E, Bier E. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development. 1997 Jan;124(1):21-32.
  68. Yu K, Sturtevant MA, Biehs B, Francois V, Padgett RW, Blackman RK, Bier E.  The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development. 1996 Dec;122(12):4033-44.
  69. Biehs B, Francois V, Bier E. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev. 1996 Nov 15;10(22):2922-34.
  70. Sturtevant MA, Roark M, O'Neill JW, Biehs B, Colley N, Bier E.  The Drosophila rhomboid protein is concentrated in patches at the apical cell surface. Dev Biol. 1996 Mar 15;174(2):298-309.
  71. Schmidt J, Francois V, Bier E, Kimelman D. Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning. Development. 1995 Dec;121(12):4319-28.
  72. Emery JF, Bier E.  Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Development. 1995 Nov;121(11):3549-60.
  73. Roark M, Sturtevant MA, Emery J, Vaessin H, Grell E, Bier E. scratch, a pan-neural gene encoding a zinc finger protein related to snail, promotes neuronal development. Genes Dev. 1995 Oct 1;9(19):2384-98.
  74. Guo M, Bier E, Jan LY, Jan YN. tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. Neuron. 1995 May;14(5):913-25.
  75. Sturtevant MA, Bier E. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development. 1995 Mar;121(3):785-801.
  76. Francois V, Bier E. Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation. Cell. 1995 Jan 13;80(1):19-20. No abstract available.
  77. Francois V, Solloway M, O'Neill JW, Emery J, Bier E. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 1994 Nov 1;8(21):2602-16.
  78. O'Neill JW, Bier E.  Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques. 1994 Nov;17(5):870, 874-5.
  79. Fristrom D, Gotwals P, Eaton S, Kornberg TB, Sturtevant M, Bier E, Fristrom JW.  Blistered: a gene required for vein/intervein formation in wings of Drosophila. Development. 1994 Sep;120(9):2661-71.
  80. Sturtevant MA, O'Neill JW, Bier E. Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development. 1994 Sep;120(9):2593-600.
  81. Noll R, Sturtevant MA, Gollapudi RR, Bier E. New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development. 1994 Aug;120(8):2329-38.
  82. Ip YT, Levine M, Bier E. Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development. 1994 Jan;120(1):199-207.
  83. Sturtevant MA, Roark M, Bier E. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 1993 Jun;7(6):961-73.
  84. Bier E, Vaessin H, Younger-Shepherd S, Jan LY, Jan YN. deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product. Genes Dev. 1992 Nov;6(11):2137-51.
  85. Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN. deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell. 1992 Sep 18;70(6):911-22.
  86. Ip YT, Park RE, Kosman D, Bier E, Levine M. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 1992 Sep;6(9):1728-39.
  87. Rutledge BJ, Zhang K, Bier E, Jan YN, Perrimon N. The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 1992 Aug;6(8):1503-17.
  88. Bellen HJ, Vaessin H, Bier E, Kolodkin A, D'Evelyn D, Kooyer S, Jan YN. The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics. 1992 Jun;131(2):365-75.
  89. Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 1991 Nov 29;67(5):941-53.
  90. Bier E, Jan LY, Jan YN. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 1990 Feb;4(2):190-203. Erratum in: Genes Dev 1990 Apr;4(4):680-1.
  91. Vaessin H, Caudy M, Bier E, Jan LY, Jan YN. Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol. 1990;55:239-45. Review.
  92. Bier E, Vaessin H, Shepherd S, Lee K, McCall K, Barbel S, Ackerman L, Carretto R, Uemura T, Grell E, et al. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 1989 Sep;3(9):1273-87.
  93. Bier E, Ackerman L, Barbel S, Jan L, Jan YN.  Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science. 1988 May 13;240(4854):913-6.